Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis
نویسندگان
چکیده
منابع مشابه
[Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis].
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are the hepatic manifestations of the metabolic syndrome. Since the prevalence of obesity and consequently of the metabolic syndrome is steadily increasing, the different types of NAFLD are nowadays the most common cause of liver injury in North America. The development of NASH and fatty liver cirrhosis occurs af...
متن کاملToll-Like Receptors in the Pathogenesis of Alcoholic Liver Disease
In the multifactorial pathophysiology of alcoholic liver disease (ALD), inflammatory cascade activation plays a central role. Recent studies demonstrated that Toll-like Receptors, the sensors of microbial and endogenous danger signals, are expressed and activated in innate immune cells as well as in parenchymal cells in the liver and thereby contribute to ALD. In this paper, we discuss the impo...
متن کاملToll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis
BACKGROUND Previously we reported that mice deficient in toll-like receptor 4 (TLR-4) signalling were protected from diet-induced non-alcoholic steatohepatitis (NASH). Another member of the toll-like receptor family, TLR-2, has been shown to play a role in lipid trafficking via uptake of diacylated lipoproteins. However, a role for TLR-2 in NASH has not been elucidated. The objectives of the cu...
متن کاملCurrent solutions for obesity-related liver disorders: non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.
o besity is a worldwide epidemic with more than 1 billion overweight adults and at least 300 million obese patients [1]. According to recent statistics from the United States, 16.9% of children and adolescents aged 2–19 years were obese in 2009–2010 and 31.8% were either overweight or obese [2]. The rise in childhood obesity has been accompanied by an increase in pediatric liver diseases: 70%–8...
متن کاملSystematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
BACKGROUND Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent cause of liver disease in Western countries. The development of non-alcoholic steatohepatitis (NASH) and fibrosis identifies an at-risk group with increased risk of cardiovascular and liver-related deaths. The identification and management of this at-risk group remains a clinical challenge. AIM To perform a sys...
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ژورنال
عنوان ژورنال: Journal of Gastroenterology and Hepatology
سال: 2013
ISSN: 0815-9319
DOI: 10.1111/jgh.12019